MannaLife Methyl-B-Complex

Methyl B Complex is a balanced and comprehensive B
complex supplement that contains eight essential B vitamins,
along with choline, inositol, and folate as Quatrefolic™ -
100% 5-MTHF, the biologically active form of folic acid for
optimal methylation. B vitamins have historically been
taken together for their synergistic role in supporting
energy production, immune health, cardiovascular health
and neurological health. Adequate B vitamins are essential
for maintaining energy levels and additional intake is often
needed by those with high levels of stress. Methyl B Complex
offers high-quality nutrients, which help to build a healthy
micronutrient reserve.
Overview
A wide and complex variety of B vitamins is essential for the
body to convert food into cellular energy. These water-soluble
groups of vitamins are first absorbed in the small intestine and
then travel to the liver where they are biotransformed into their
active coenzyme forms. One of the key roles of B vitamins is to
serve as prime coenzymes for the Kreb’s cycle, the biochemical
pathway responsible for maintaining energy production in the
form of cellular energy. In addition, B vitamins, particularly
folic acid, B6 and B12, are critical for proper methylation,
a biochemical process that helps convert the problematic
amino acid metabolite homocysteine into the amino acids
methionine and cysteine. This process is vital for supporting
cardiovascular and mental health, a healthy nervous system,
regulating gene expression, proper energy metabolism, as well
as immune and nerve cell function. Methylation occurs billions
of times every second and helps the body to repair DNA on a
continual basis. However, when methylation processes in the
body slow down, an increase in the breakage of DNA strands
can occur. In addition to maintaining DNA repair, methylation
reactions help maintain optimal neurotransmitter production,
homocysteine balance for cardiovascular health, recycle
molecules that are required for detoxification and support a
healthy inflammatory response. Proper methylation can be
inhibited by nutrient deficiencies including folate, B2, B6 and B12.
Deficiency†
Deficiency in any of the B vitamins can create a breakdown of
metabolic processes that protect health. Many medications
deplete certain B-vitamins including acetaminophen, aspirin,
ibuprofen, oral contraceptives and SSRIs, along with stress and
poor diet. Deficiencies of folic acid, B6 and B12 can specifically
impair proper methylation, which affects many aspects of health.
Folate†
Folate is a water soluble member of the B complex vitamins that
is critical for maintaining optimal methylation. Folate is found
naturally in foods such as fruits and dark leafy vegetables, but
can be easily destroyed by cooking or processing. Additionally,
enzyme defects, malabsorption and congenital deficiency of
5-methylenetetrahydrofolate reductase (5-MTHFR), an enzyme
required for the conversion of folic acid to its bioactive form
5-methyltetrahydrofolate (5-MTHF), can result in an impaired
ability to activate folic acid. In individuals with a genetic defect
of this enzyme, supplementation with 5-MTHF has been shown
to be beneficial.1 5-MTHF is required as a methyl group donor
for the production of mood regulating neurotransmitters
such as serotonin, the synthesis of melatonin, as well as
DNA production and repair.1 5-MTHF also donates its methyl
group to vitamin B12 (cobalamin), forming methylcobalamin.
Methylcobalamin helps convert the amino acid metabolite
CLINICAL APPLICATIONS
ESSENTIAL VITAMINS
† These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure, or prevent any disease.
homocysteine into the amino acid methionine. Consistent
recycling of homocysteine is vital to supporting cardiovascular
and arterial health.1
Thiamine (Vitamin B1)†
While naturally abundant in whole grains, thiamine is lost
in many of the over-processed grains commonly consumed
today.2 Thiamine is an essential co-factor in the production
of ATP in the cells’ Kreb’s cycle, and is also needed for the
metabolism of fats, proteins and carbohydrates.3 A recent
randomized double blind placebo-controlled trial found that
supplementation with high-dose thiamine also supports
blood sugar balance.4
Riboflavin (Vitamin B2)†
Riboflavin is a precursor to flavin adenine dinucleodtide (FAD)
and flavin mononucleotide (FMN), both of which are central
to energy production, intermediary metabolism, and act as
powerful antioxidants.5 Riboflavin-depleted cells have been
found to display signs of greater oxidative stress and disrupted
energy generation.6 Studies have also shown that optimal
riboflavin status has been found to help maintain healthy
blood pressure already within normal range in patients with
certain genetic predispositions.7
Niacin†
Niacin is a cofactor in the mitochondrial respiratory chain, which
produces cellular energy.8 In the body, niacin is transformed
into NAD (Nicotinamide adenine dinucleotide) and NADP
(Nicotinamide adenine dinucleotide phosphate), which both
play a role in oxidation reduction reactions in cells.9 Niacin
or nicotinic acid has a long history of use in cardiovascular
health, having been shown in numerous studies to support
endothelial health.10,11
Vitamin B6†
Vitamin B6 is involved in over 100 enzymatic reactions in the
body and is essential for gluconeogenesis, lipid metabolism,
neurotransmitter formation, immune health and hormone
modulation,11 and is essential in methylation, for the
breakdown of homocysteine. A large, prospective study found
that women who consumed, on average, 4.6 mg of vitamin
B6 daily had significantly better markers of cardiovascular
health compared to women who consumed an average of 1.1
mg daily.12 In addition, vitamin B6 has been found to promote
normal lymphocyte proliferation and interleukin-2 production
in older people, both of which are important for optimal
immune function.13,14
Vitamin B12†
Vitamin B12, found only in organ meats, seafood and egg
yolks, often becomes deficient in vegan and vegetarian
diets. The vitamin is essential for the metabolism of fats and
carbohydrates, the synthesis of proteins, and also plays a role
in regulating mitochondrial enzymes and energy metabolism,
as well as neurological health.8 In a population study of 700
women aged 65 and over, more optimal B12 levels were found
to be associated with better mood balance and health.17
Biotin†
Synthesized by the bacteria in the gut in addition to certain
foods,18 biotin and its cofactors are involved in metabolism of
fatty acids, amino acids and utilization of B vitamins.8 Biotin
has also been found to support healthy blood sugar both
in animal19 and human studies. A randomized, double-blind
placebo-controlled clinical trial conducted among 70 patients,
age 5-25 years old with blood sugar concerns found biotin
administration to serve as an adjuvant, which improved sugar
management, as well as the balance of blood fats.20
Pantothenic Acid†
Pantothenic acid and its biologically active derivative, CoA,
are essential to the synthesis of fatty acids, membrane
phospholipids, amino acids, steroid hormones, and energy
production.20 95% of CoA is found in the mitochondria.[21]
Pantothenic acid has also been shown to have a balancing
effect on blood fats in animal studies22 and has also been
shown in the research to support wound healing.23
Choline Bitartrate†
Though not technically a B vitamin, choline is often associated
with B-vitamins. It is important in the construction of cell
membranes and plasma lipoproteins, plays a role in cell signaling
and in the synthesis of acetylcholine (a neurotransmitter), and is
vital for brain development.24 The oxidized form of choline acts
as a methyl donor in the methionine cycle.25 In a study of 51
men and women, subjects fed an intentionally choline-deficient
diet had greater levels of lymphocyte and DNA damage.26
Directions
1 or more capsules per day or as recommended by your health
care professional.
Does Not Contain
Does not contain gluten, corn, yeast, artificial colors
and flavors.
Cautions
If you are pregnant or nursing, consult your physician before
taking this product.