{"product_id":"mannalife-methyl-b-complex","title":"MannaLife Methyl-B-Complex","description":"\u003cp\u003eMethyl B Complex is a balanced and comprehensive B\u003cbr\u003ecomplex supplement that contains eight essential B vitamins,\u003cbr\u003ealong with choline, inositol, and folate as Quatrefolic™ -\u003cbr\u003e100% 5-MTHF, the biologically active form of folic acid for\u003cbr\u003eoptimal methylation. B vitamins have historically been\u003cbr\u003etaken together for their synergistic role in supporting\u003cbr\u003eenergy production, immune health, cardiovascular health\u003cbr\u003eand neurological health. Adequate B vitamins are essential\u003cbr\u003efor maintaining energy levels and additional intake is often\u003cbr\u003eneeded by those with high levels of stress. Methyl B Complex\u003cbr\u003eoffers high-quality nutrients, which help to build a healthy\u003cbr\u003emicronutrient reserve.\u003cbr\u003eOverview\u003cbr\u003eA wide and complex variety of B vitamins is essential for the\u003cbr\u003ebody to convert food into cellular energy. These water-soluble\u003cbr\u003egroups of vitamins are first absorbed in the small intestine and\u003cbr\u003ethen travel to the liver where they are biotransformed into their\u003cbr\u003eactive coenzyme forms. One of the key roles of B vitamins is to\u003cbr\u003eserve as prime coenzymes for the Kreb’s cycle, the biochemical\u003cbr\u003epathway responsible for maintaining energy production in the\u003cbr\u003eform of cellular energy. In addition, B vitamins, particularly\u003cbr\u003efolic acid, B6 and B12, are critical for proper methylation,\u003cbr\u003ea biochemical process that helps convert the problematic\u003cbr\u003eamino acid metabolite homocysteine into the amino acids\u003cbr\u003emethionine and cysteine. This process is vital for supporting\u003cbr\u003ecardiovascular and mental health, a healthy nervous system,\u003cbr\u003eregulating gene expression, proper energy metabolism, as well\u003cbr\u003eas immune and nerve cell function. Methylation occurs billions\u003cbr\u003eof times every second and helps the body to repair DNA on a\u003cbr\u003econtinual basis. However, when methylation processes in the\u003cbr\u003ebody slow down, an increase in the breakage of DNA strands\u003cbr\u003ecan occur. In addition to maintaining DNA repair, methylation\u003cbr\u003ereactions help maintain optimal neurotransmitter production,\u003cbr\u003ehomocysteine balance for cardiovascular health, recycle\u003cbr\u003emolecules that are required for detoxification and support a\u003cbr\u003ehealthy inflammatory response. Proper methylation can be\u003cbr\u003einhibited by nutrient deficiencies including folate, B2, B6 and B12.\u003cbr\u003eDeficiency†\u003cbr\u003eDeficiency in any of the B vitamins can create a breakdown of\u003cbr\u003emetabolic processes that protect health. Many medications\u003cbr\u003edeplete certain B-vitamins including acetaminophen, aspirin,\u003cbr\u003eibuprofen, oral contraceptives and SSRIs, along with stress and\u003cbr\u003epoor diet. Deficiencies of folic acid, B6 and B12 can specifically\u003cbr\u003eimpair proper methylation, which affects many aspects of health.\u003cbr\u003eFolate†\u003cbr\u003eFolate is a water soluble member of the B complex vitamins that\u003cbr\u003eis critical for maintaining optimal methylation. Folate is found\u003cbr\u003enaturally in foods such as fruits and dark leafy vegetables, but\u003cbr\u003ecan be easily destroyed by cooking or processing. Additionally,\u003cbr\u003eenzyme defects, malabsorption and congenital deficiency of\u003cbr\u003e5-methylenetetrahydrofolate reductase (5-MTHFR), an enzyme\u003cbr\u003erequired for the conversion of folic acid to its bioactive form\u003cbr\u003e5-methyltetrahydrofolate (5-MTHF), can result in an impaired\u003cbr\u003eability to activate folic acid. In individuals with a genetic defect\u003cbr\u003eof this enzyme, supplementation with 5-MTHF has been shown\u003cbr\u003eto be beneficial.1 5-MTHF is required as a methyl group donor\u003cbr\u003efor the production of mood regulating neurotransmitters\u003cbr\u003esuch as serotonin, the synthesis of melatonin, as well as\u003cbr\u003eDNA production and repair.1 5-MTHF also donates its methyl\u003cbr\u003egroup to vitamin B12 (cobalamin), forming methylcobalamin.\u003cbr\u003eMethylcobalamin helps convert the amino acid metabolite\u003cbr\u003eCLINICAL APPLICATIONS\u003cbr\u003eESSENTIAL VITAMINS\u003cbr\u003e† These statements have not been evaluated by the Food and Drug Administration.\u003cbr\u003eThis product is not intended to diagnose, treat, cure, or prevent any disease.\u003cbr\u003ehomocysteine into the amino acid methionine. Consistent\u003cbr\u003erecycling of homocysteine is vital to supporting cardiovascular\u003cbr\u003eand arterial health.1\u003cbr\u003eThiamine (Vitamin B1)†\u003cbr\u003eWhile naturally abundant in whole grains, thiamine is lost\u003cbr\u003ein many of the over-processed grains commonly consumed\u003cbr\u003etoday.2 Thiamine is an essential co-factor in the production\u003cbr\u003eof ATP in the cells’ Kreb’s cycle, and is also needed for the\u003cbr\u003emetabolism of fats, proteins and carbohydrates.3 A recent\u003cbr\u003erandomized double blind placebo-controlled trial found that\u003cbr\u003esupplementation with high-dose thiamine also supports\u003cbr\u003eblood sugar balance.4\u003cbr\u003eRiboflavin (Vitamin B2)†\u003cbr\u003eRiboflavin is a precursor to flavin adenine dinucleodtide (FAD)\u003cbr\u003eand flavin mononucleotide (FMN), both of which are central\u003cbr\u003eto energy production, intermediary metabolism, and act as\u003cbr\u003epowerful antioxidants.5 Riboflavin-depleted cells have been\u003cbr\u003efound to display signs of greater oxidative stress and disrupted\u003cbr\u003eenergy generation.6 Studies have also shown that optimal\u003cbr\u003eriboflavin status has been found to help maintain healthy\u003cbr\u003eblood pressure already within normal range in patients with\u003cbr\u003ecertain genetic predispositions.7\u003cbr\u003eNiacin†\u003cbr\u003eNiacin is a cofactor in the mitochondrial respiratory chain, which\u003cbr\u003eproduces cellular energy.8 In the body, niacin is transformed\u003cbr\u003einto NAD (Nicotinamide adenine dinucleotide) and NADP\u003cbr\u003e(Nicotinamide adenine dinucleotide phosphate), which both\u003cbr\u003eplay a role in oxidation reduction reactions in cells.9 Niacin\u003cbr\u003eor nicotinic acid has a long history of use in cardiovascular\u003cbr\u003ehealth, having been shown in numerous studies to support\u003cbr\u003eendothelial health.10,11\u003cbr\u003eVitamin B6†\u003cbr\u003eVitamin B6 is involved in over 100 enzymatic reactions in the\u003cbr\u003ebody and is essential for gluconeogenesis, lipid metabolism,\u003cbr\u003eneurotransmitter formation, immune health and hormone\u003cbr\u003emodulation,11 and is essential in methylation, for the\u003cbr\u003ebreakdown of homocysteine. A large, prospective study found\u003cbr\u003ethat women who consumed, on average, 4.6 mg of vitamin\u003cbr\u003eB6 daily had significantly better markers of cardiovascular\u003cbr\u003ehealth compared to women who consumed an average of 1.1\u003cbr\u003emg daily.12 In addition, vitamin B6 has been found to promote\u003cbr\u003enormal lymphocyte proliferation and interleukin-2 production\u003cbr\u003ein older people, both of which are important for optimal\u003cbr\u003eimmune function.13,14\u003cbr\u003eVitamin B12†\u003cbr\u003eVitamin B12, found only in organ meats, seafood and egg\u003cbr\u003eyolks, often becomes deficient in vegan and vegetarian\u003cbr\u003ediets. The vitamin is essential for the metabolism of fats and\u003cbr\u003ecarbohydrates, the synthesis of proteins, and also plays a role\u003cbr\u003ein regulating mitochondrial enzymes and energy metabolism,\u003cbr\u003eas well as neurological health.8 In a population study of 700\u003cbr\u003ewomen aged 65 and over, more optimal B12 levels were found\u003cbr\u003eto be associated with better mood balance and health.17\u003cbr\u003eBiotin†\u003cbr\u003eSynthesized by the bacteria in the gut in addition to certain\u003cbr\u003efoods,18 biotin and its cofactors are involved in metabolism of\u003cbr\u003efatty acids, amino acids and utilization of B vitamins.8 Biotin\u003cbr\u003ehas also been found to support healthy blood sugar both\u003cbr\u003ein animal19 and human studies. A randomized, double-blind\u003cbr\u003eplacebo-controlled clinical trial conducted among 70 patients,\u003cbr\u003eage 5-25 years old with blood sugar concerns found biotin\u003cbr\u003eadministration to serve as an adjuvant, which improved sugar\u003cbr\u003emanagement, as well as the balance of blood fats.20\u003cbr\u003ePantothenic Acid†\u003cbr\u003ePantothenic acid and its biologically active derivative, CoA,\u003cbr\u003eare essential to the synthesis of fatty acids, membrane\u003cbr\u003ephospholipids, amino acids, steroid hormones, and energy\u003cbr\u003eproduction.20 95% of CoA is found in the mitochondria.[21]\u003cbr\u003ePantothenic acid has also been shown to have a balancing\u003cbr\u003eeffect on blood fats in animal studies22 and has also been\u003cbr\u003eshown in the research to support wound healing.23\u003cbr\u003eCholine Bitartrate†\u003cbr\u003eThough not technically a B vitamin, choline is often associated\u003cbr\u003ewith B-vitamins. It is important in the construction of cell\u003cbr\u003emembranes and plasma lipoproteins, plays a role in cell signaling\u003cbr\u003eand in the synthesis of acetylcholine (a neurotransmitter), and is\u003cbr\u003evital for brain development.24 The oxidized form of choline acts\u003cbr\u003eas a methyl donor in the methionine cycle.25 In a study of 51\u003cbr\u003emen and women, subjects fed an intentionally choline-deficient\u003cbr\u003ediet had greater levels of lymphocyte and DNA damage.26\u003cbr\u003eDirections\u003cbr\u003e1 or more capsules per day or as recommended by your health\u003cbr\u003ecare professional.\u003cbr\u003eDoes Not Contain\u003cbr\u003eDoes not contain gluten, corn, yeast, artificial colors\u003cbr\u003eand flavors.\u003cbr\u003eCautions\u003cbr\u003eIf you are pregnant or nursing, consult your physician before\u003cbr\u003etaking this product.\u003c\/p\u003e","brand":"Michael Turner MD","offers":[{"title":"Default Title","offer_id":68002500215027,"sku":"68002500215027","price":23.9,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0645\/5053\/5411\/files\/TUR818_360060_Methyl-BComplex.png?v=1794341467","url":"https:\/\/michaelkturner.myshopify.com\/products\/mannalife-methyl-b-complex","provider":"Michael Turner MD","version":"1.0","type":"link"}